Our results strongly suggest that lennerts lymphoma is a cd4positive t cell lymphoma. Peripheral tcell lymphoma excluding anaplastic largecell. Tcell lymphoma of thyroid gland with lennert type of. Often used to denote malignant lymphoma, classifications of which are based on predominant cell type and degree of differentiation. Effective treatment of a peripheral tcell lymphoma lymphoepitheloid cell variant lennert s lymphoma refractory to chemotherapy with the cd52 antibody alemtuzumab. The name lennerts lymphoma has been applied to a form of malignant lymphoma with a high content of epithelioid histiocytes which was first described. Two cases of a recently described lymphoproliferative disorder called lennerts lymphoma are presented. It is also known as lymphoepithelioid lymphoma the peripheral tcell lymphoma or ptcl is a type of nodal or soft tissue lymphoma, which are generally restricted to lymph nodes and do not enter the bloodstream until later stages of the disease. The rare entity of primary tcell lymphoma of thyroid gland may pose great diagnostic and therapeutic challenges to the pathologist and clinician. For personal accounts or managers of institutional accounts. This provides strong evidence that lennerts lymphoma is a t. Lennerts lymphoma with transformation to malignant.
Lennerts lymphoma definition of lennerts lymphoma by the. Additionally, the results suggest that a subgroup of ptclsu, distinct from aitl and including some cases denominated as alcl, may also be derived from t fh cells, although they develop along a distinct pathogenic pathway. This study aims to analyze the clinical, morphologic, and immunophenotypic profile of cases of lennert s lymphoma from our country and determines the utility of tcell receptor tcr gene rearrangement in the diagnosis. Lennert lymphoma ll, or the lymphoepithelioid variant of peripheral tcell lymphoma, is an uncommon entity which was first characterized in 1952 by karl. It is suggested that mycologic cultures as well as histopathological examinations of surgical specimens be performed routinely in. The disease cannot be separated from the broad category of peripheral tcell lymphoma ptl. The implication of these findings in relation to the nature of lennert s lymphoma are briefly discussed. This report highlights the role of idiopathic immunosuppression in lymphoma patients.
A patient with lennerts lymphoma malignant lymphoma with a high content of epithelioid histiocytes is described. Our recent report of expression of cxcl, a chemokine critical for germinal. A 66yearold, previously well woman presented with a 2month history of loss of appetite, nausea, tiredness and weight loss. Treatment options are based on the type and stage of lymphoma and the age and overall health of the patient. Histoplasma capsulatum was cultured from splenic tissue obtained at diagnostic laparotomy in a patient with lennerts lymphoma. Peripheral tcell lymphoma with follicular tcell markers. Lennert is also recognized for first describing a variant of peripheral tcell lymphoma in 1952, which he termed lymphoepithelioid lymphoma. The germinal center thelper cell has been proposed as the cell of origin for angioimmunoblastic tcell lymphoma. All cases diagnosed as lennerts lymphoma during the period of january. Morphologically and immunophenotypically heterogeneous group of nodal t cell lymphomas that do not meet the diagnostic criteria of one of the other whodefined tcell lymphoma categories.
The primary extranodal ptcl subtypes covered by the present guidelines comprise enteropathyassociated tcell lymphoma eatl, extranodal natural killertcell lymphoma enktcl, and hepatosplenic tcell lymphoma hstcl. On 27 august 2012, karl lennert, emeritus professor of pathology at. Lennerts lymphoma is a rare variant of peripheral t. Lennert s lymphoma is a rare variant of peripheral tcell lymphoma ptcl not otherwise specified nos. Lennerts lymphoma can be recognized by the presence of numerous epithelioid histiocytes usually grouped in small clusters. Lymphoepithelioid lymphoma lennerts lymphoma is a monoclonal. Cleveland, oh we recently diagnosed and studied a case of lennerts lymphoma in a young black man who presented with a chronic pyoderma and multiple cutaneous infections of viral origin. The lymphatic system is part of your bodys immune system. Lennerts lymphoma, or malignant lymphoma with a high. A heterogeneous category of nodal and extranodal mature t cell lymphomas which do not correspond to any of the specifically defined entities of mature t cell lymphoma in the current classification who classification of tumours of haematopoietic and. Lymphoepithelioid variant lennerts lymphoma is a distinct morphologic variant of peripheral tcell lymphoma that has numerous epithelioid histiocytes. Lennert lymphoma ll is a lymphoepithelioid morphological variant of peripheral tcell lymphomanot otherwise specified ptclnos, clinically characterized by better prognosis if compared with other ptclnos. There are very few case and short series reports of these tumors describing their varied clinicopathologic features in english literature.
Successful allogeneic stem cell transplantation for. We report a case of mature tcell lymphoma of thyroid in a 26 year old male, with unique pseudogranulomatous. Lennerts lymphoma definition of lennerts lymphoma by. In total, lennert contributed over 300 scholarly papers and 4 textbooks to the medical literature during his working life. The strain reverted slowly to the yeast phase and was difficult. Lymphnode calcification in lennerts lymphoma the british. Lymphoma is a cancer that develops in the white blood cells lymphocytes of the lymphatic system. Expression of cxcl, a chemokine highly upregulated in. When treatment is required for lymphoma, one or more of the following therapies may be. The aim of this study was to further characterize this tumour.
Lennerts lymphoma synonyms, lennerts lymphoma pronunciation, lennerts lymphoma translation, english dictionary definition of lennerts lymphoma. Peripheral tcell lymphoma blood american society of. Lennerts lymphoma is a rare variant of peripheral tcell lymphoma ptcl not otherwise specified nos rich in epithelioid histiocytes. Effective treatment of a peripheral tcell lymphoma. They are seen in this image as lighter pink areas in between clusters of small lymphocytes. Progressive transformation of germinal centers ptgcs is a benign disease of the lymph nodes that is rarely associated with hodgkin disease. Treating nonhodgkin lymphoma american cancer society. Cytogenetic abnormalities indicate that lennert s lymphoma is of t cell origin. Sep 10, 2019 lennert lymphoma ll is a lymphoepithelioid morphological variant of peripheral tcell lymphomanot otherwise specified ptclnos, clinically characterized by better prognosis if compared with other ptclnos.
All cases showed rearrangement of the gene coding for the. Diagnostic reed sternberg cells are usually found without difficulty in mixedcellularity hodgkin lymphoma. In both cases, the proliferation evolved in we use cookies to enhance your experience on our website. Jan 28, 2014 a case of lennert s lymphoma with calcification seen in a mesenteric lymph node mass at presentation is described. This study aims to analyze the clinical, morphologic, and immunophenotypic profile of cases of lennerts lymphoma from our country and determines the utility of tcell receptor tcr gene rearrangement in the diagnosis. To revise 25 cases selected from karl lennerts personal archive 21 and bologna and frankfurt registries four because of cytological similarities. We believe this to be the first report of this association. Cytogenetic abnormalities indicate that lennerts lymphoma is of t cell origin. Since then, it has been called the kiel classification. Lennert s lymphoma is a rare variant of peripheral tcell lymphoma ptcl not otherwise specified nos rich in epithelioid histiocytes. Although well characterized as far as morphology and phenotype are concerned, very little is known regarding its molecular features. Cleveland, oh we recently diagnosed and studied a case of lennert s lymphoma in a young black man who presented with a chronic pyoderma and multiple cutaneous infections of viral origin. Classification historically a mess 1940s gail and mallory 1950s rappaport 1970s lukescollins 1970s kiel 1982 working 1994 real 2001, 2008 who 2 3. Lymphoepithelioid lymphoma lennert s lymphoma is a monoclonal proliferation of helperinducer t cells.
Lymphoepithelioid lymphoma lennerts lymphoma was first described as a special variant of hodgkins disease. Transcriptional analysis of lennert lymphoma reveals a. Lennert s lymphoma can be recognized by the presence of numerous epithelioid histiocytes usually grouped in small clusters. The implication of these findings in relation to the nature of lennerts lymphoma are briefly discussed. The history of lymphoma classification and the 2017 revision german ott department of clinical pathology, robertboschkrankenhaus and dr. Lennert lymphoma ll, or the lymphoepithelioid variant of peripheral tcell lymphoma, is an uncommon entity which was first characterized in 1952 by karl lennert. It is suggested that mycologic cultures as well as histopathological examinations of surgical specimens be performed routinely in immunologically. Lennerts lymphoma was first described as a special variant of hodgkins disease. It is now commonly and eponymously called lennert s lymphoma.
Nodal peripheral t cell lymphoma unspecified surgical. Ii i ii ii i lennert s lymphoma presenting with clusters of cutaneous infection isaac zamora, m. A distinct clinicopathologic entity and a form of socalled lennerts lymphoma. Malignant lymphomas other than hodgkins disease histology. Histoplasma capsulatum was cultured from splenic tissue obtained at diagnostic laparotomy in a patient with lennert s lymphoma. A 66yearold, previously well woman presented with a 2month history of. For some types of lymphoma, if the disease is advanced but slowgrowing indolent, a waitandsee approach may be an option. Peripheral tcell lymphoma ptcl is rare in most parts of the world. Pdf on jan 1, 2015, akhil kapoor and others published lennert s lymphoma a diagnostic dilemma. Lymphoepithelioid lymphoma lennert s lymphoma was first described as a special variant of hodgkins disease. Sa ss lymphoepithelioid cellular lymphoma lennerts lymphoma. The patient had no clinical features suggesting histoplasmosis, and the organism was not seen on histologic specimens.
It is suggested that mycologic cultures as well as. Pdf on jan 1, 2015, akhil kapoor and others published lennerts lymphoma a diagnostic dilemma. Lennerts lymphoma diffuse mixed tcell ml with excessive histiocytes. Download fulltext pdf update on classification of lymphomas article pdf available in dental hypotheses 41. Mar 16, 2016 the rare entity of primary tcell lymphoma of thyroid gland may pose great diagnostic and therapeutic challenges to the pathologist and clinician. Oct 20, 2011 peripheral t cell lymphomas with follicular t helper phenotype. This lesion is characterized by a high percentage of epithelioid and t cells and rarely. Lennerts lymphoma presenting with clusters of cutaneous. Lennert lymphoma ll is a lymphoepithelioid morphological variant of peripheral tcell lymphomanot otherwise specified ptclnos. By continuing to use our website, you are agreeing to our use of cookies.
Older lymphoma classification systems include the rappaport system, which was used until the mid 1970s, 1 the kiel system, introduced in 1974, 2 and the national cancer institutes working formulation, introduced in the 1980s. This study aims to analyze the clinical, morphologic, and immunophenotypic profile of cases of lennert. Follicular lymphoma is a common type of nhl, and occurs almost exclusively in adults. Frontiers transcriptional analysis of lennert lymphoma. Lennert lymphoma is a systemic tcell lymphoma that presents with cutaneous skin lesions roughly 10% of the time 739 it is also known as lymphoepithelioid variant of peripheral tcell lymphoma. A case of lennerts lymphoma journal of clinical pathology. Lennert s lymphoma, or malignant lymphoma with a high content of epithelioid histiocytes, is an uncommon variant of nonhodgkins lymphoma. Histoplasmosis and lennerts lymphoma jama internal. In joint discussions in 1974, the club worked out a new terminology that was acceptable to all members and will hopefully be acceptable to other pathologists. Any of various malignant tumors that arise from the lymphocytic cells of the immune system.
Effective treatment of a peripheral tcell lymphomalymphoepitheloid cell variant lennerts lymphoma refractory to chemotherapy with the cd52 antibody alemtuzumab. Kim h, jacobs c, warnke ra, dorfman rf 1978 malignant lymphoma with a high content of epithelioid histiocytes. Lymphoepithelioid cell lymphoma lennert lymphoma t cell lymphoma with high content of epithelioid lymphocytes. A heterogeneous category of nodal and extranodal mature t cell lymphomas which do not correspond to any of the specifically defined entities of mature t cell lymphoma in the current classification who classification of tumours of haematopoietic and lymphoid tissues, 4th edition, lyon 2008. This lesion is characterized by a high percentage of epithelioid and t cells and rarely contains the classical hodgkinsreedsternberg cells. Pathology outlines peripheral t cell lymphoma, not. In addition, lymphoepithelioid lennerts lymphoma was considered to represent a cytologic variant. The history of lymphoma classification and the 2017 revision. A patient with lennert s lymphoma malignant lymphoma with a high content of epithelioid histiocytes is described. In this study, we investigated the transcriptional. Lennerts lymphoma article about lennerts lymphoma by.
A case of lennerts lymphoma with calcification seen in a mesenteric lymph node mass at presentation is described. Non hodgkin lymphoma by dr tashi agarwal moderator. Ii i ii ii i lennerts lymphoma presenting with clusters of cutaneous infection isaac zamora, m. We recently diagnosed and studied a case of lennerts lymphoma in a young black man who presented with a chronic pyoderma and multiple cutaneous infections of viral origin. Sa ss lymphoepithelioid cellular lymphoma lennerts. The case is unique in that hepatosplenomegaly was the presenting feature, the diagnosis was made on bone marrow biopsy and the disorder appears to have run a benign course.
Peripheral t cell lymphomas with follicular t helper. Lennert lymphoma is a rare type of nonhodgkin lymphoma that is a variant of peripheral tcell lymphoma. Ptl is characterized by a heterogeneous cellular composition with small and large cells with an inflammarory background. Peripheral t cell lymphomas with follicular t helper phenotype. Lennerts lymphoma is a rare variant of peripheral tcell lymphoma ptcl not otherwise specified nos. Lymphoepithelioid lymphoma lennerts lymphoma is a monoclonal proliferation of helperinducer t cells. Lennerts lymphoma article about lennerts lymphoma by the. Its important to weigh the benefits of each treatment option against the possible risks and side effects. Lennerts lymphoma is a rare variant of peripheral tcell lymphoma ptcl.
Margarete fischerbosch institute of clinical pharmacology, stuttgart esmo perceptorship on lymphoma, lugano 2018. Revising the historical collection of epithelioid cell. Lymph node, mixedcellularity hodgkin lymphoma disease. Full text get a printable copy pdf file of the complete article 3. We determined that ptgcs can be seen simultaneously with lymphoma and.
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